Activation succinate dehydrogenation in rat liver by noradrenaline, cAMP and acute cooling

Administration of noradrenaline in a dose of 11 mumol/kg activates succinate dehydrogenase (SDH) in the rat liver. On incubation of liver homogenate with noradrenaline (10(-6) M), cAMP (10(-6) M) and NaF (10(-2) M), a nonhormonal activator of adenylate cyclase, SDH was found to be activated by 20--3...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 92; no. 8; p. 33
Main Authors Kulinskii, V I, Kuntsevich, A K, Trufanova, L V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.08.1981
Subjects
Animals
Catecholamines - physiology
Cold Temperature
Cyclic AMP - pharmacology
Drug Interactions
Enzyme Activation
Female
Liver - enzymology
Male
Norepinephrine - pharmacology
Rats
Rats, Inbred Strains
Sodium Fluoride - pharmacology
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Summary:Administration of noradrenaline in a dose of 11 mumol/kg activates succinate dehydrogenase (SDH) in the rat liver. On incubation of liver homogenate with noradrenaline (10(-6) M), cAMP (10(-6) M) and NaF (10(-2) M), a nonhormonal activator of adenylate cyclase, SDH was found to be activated by 20--30% in all the cases. The effects of noradrenaline and cAMP did not sum up. It seems likely that SDH activation by catecholamines is mediated by cAMP. Acute cooling (--17 degrees C) stimulates SDH via endogenous catecholamines, since this effect is completely reversed by the beta-adrenolytic inderal.
ISSN:0365-9615