Rapidly evolving pulmonary bullous degeneration in HIV-infected patients. Description of 4 cases and review of the literature

Cavitary lung lesions are common in intravenous drug-addicts (IVDA) and in AIDS patients. Four cases are reported of IVDA patients with HIV positive serology who developed an initially thick-walled lesion, which grew rapidly and evolved into bullous lesions. The negative results in microbiological i...

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Bibliographic Details
Published inRevista clínica espanõla Vol. 194; no. 7; p. 547
Main Authors Prada Pardal, J L, Villanueva Marcos, J L, Kindelán Jaquotot, J M, Jurado Jiménez, R, Escribano Fernández, J, Sánchez Guijo, P, Torre-Cisneros, J
Format Journal Article
LanguageSpanish
Published Spain 01.07.1994
Subjects
Adult
HIV Seropositivity - complications
Humans
Lung Diseases - diagnostic imaging
Lung Diseases - etiology
Male
Radiography
Substance Abuse, Intravenous - complications
Tuberculosis, Pulmonary - complications
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Summary:Cavitary lung lesions are common in intravenous drug-addicts (IVDA) and in AIDS patients. Four cases are reported of IVDA patients with HIV positive serology who developed an initially thick-walled lesion, which grew rapidly and evolved into bullous lesions. The negative results in microbiological investigations for Pneumocystis carinii, Nocardia spp., staphylococci; the topographic superposition on a previous tuberculous lesion; a prolonged asymptomatic period; and a particularly rapid evolution in all cases led us to consider the rapidly evolving bullous degeneration to be more than a casual finding. Previous infection with M. tuberculosis in AIDS patients might somehow influence on the later development of a rapidly growing, fatal, bullous degenerative lesion. The elucidation of the pathogenic mechanisms of these lesions was hampered by the lack of pathological studies.
ISSN:0014-2565