Mechanism of the antiherpetic action of bonafton

The mechanism of antiherpetic action of bonaphthon was studied in experimental herpetic keratitis of rabbits infected with herpes simplex type I virus (Koptev and IC strains). Electron microscopy demonstrated that the drug inhibits herpes virus production and proliferation of virus infection because...

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Bibliographic Details
Published inFarmakologiia i toksikologiia Vol. 43; no. 5; p. 609
Main Authors Stebaeva, L F, Nikolaeva, I S, Pershin, G N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.1980
Subjects
Animals
Antiviral Agents
Conjunctiva - drug effects
Conjunctiva - ultrastructure
Cornea - drug effects
Cornea - ultrastructure
Drug Evaluation, Preclinical
Idoxuridine - therapeutic use
Keratitis, Dendritic - drug therapy
Keratitis, Dendritic - pathology
Microscopy, Electron
Naphthoquinones - therapeutic use
Rabbits
Time Factors
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Summary:The mechanism of antiherpetic action of bonaphthon was studied in experimental herpetic keratitis of rabbits infected with herpes simplex type I virus (Koptev and IC strains). Electron microscopy demonstrated that the drug inhibits herpes virus production and proliferation of virus infection because of partial impairment of the nucleocapsid "assembly" in the cell nucleus. It is assumed that the action of bonaphthon may be consequent on the inhibition of the cell synthesis of cytoplasmatic proteins incorporated into the capsids and on the derangement of the transport of virus capsid components to the cell nucleus, where these components are assembled. It has been shown that the intensity of virus reproduction in the cells decreases threefold under the effect of bonaphthon as compared to control.
ISSN:0014-8318