The characteristics of thrombocyte morphological structure in patients with endogenous depression during antidepressant therapy

The study of platelets surface in patients with endogenous depressions made before the beginning of therapy, 1-3 days later and during the first days of clinical recovery with scanning electron microscopy showed that the platelets of patients who had not received antidepressants were activated. More...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 114; no. 10; p. 426
Main Authors Kiktenko, A I, Trunte, K, Zlobina, G P, Brusov, O S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.10.1992
Subjects
Adolescent
Adult
Antidepressive Agents - therapeutic use
Bipolar Disorder - blood
Bipolar Disorder - drug therapy
Blood Platelets - drug effects
Blood Platelets - ultrastructure
Depressive Disorder - blood
Depressive Disorder - drug therapy
Female
Humans
Microscopy, Electron, Scanning
Middle Aged
Pseudopodia - drug effects
Pseudopodia - ultrastructure
Surface Properties
Time Factors
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Summary:The study of platelets surface in patients with endogenous depressions made before the beginning of therapy, 1-3 days later and during the first days of clinical recovery with scanning electron microscopy showed that the platelets of patients who had not received antidepressants were activated. More marked activation took place after long-term therapy in the form of platelets with distinct pseudopodia, which were 2-3 times longer than cells body and with inclination to form large aggregations. This cell type is also characterized by formation of a new type of rod platelets. It is suggested that antidepressants accumulation takes place on cell membrane during long-term therapy that causes selective or general increase of membranes permeability, cytotoxicity.
ISSN:0365-9615