Comparative study of the effectiveness of several antihypoxic agents and their combinations

In 30--60 minutes following their administration sodium oxybutyrate in a dose of 100 mg/kg, mexamine in a dose of 2.5 and 5 mg/kg and also gutimine in doses of 25,50 and 100 mg/kg under conditions of hypoxic hypoxia corresponding to an altitude of 10000 m produce a marked antihypoxic effect. A combi...

Full description

Saved in:
Bibliographic Details
Published inFarmakologiia i toksikologiia Vol. 39; no. 6; p. 696
Main Author Bykov, N P
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1976
Subjects
5-Methoxytryptamine - administration & dosage
5-Methoxytryptamine - therapeutic use
Amidines - administration & dosage
Amidines - therapeutic use
Animals
Drug Therapy, Combination
Heart Rate - drug effects
Hydroxybutyrates - administration & dosage
Hydroxybutyrates - therapeutic use
Hypoxia - drug therapy
Male
Mice
Myocardial Contraction - drug effects
Stimulation, Chemical
Thiourea - administration & dosage
Thiourea - analogs & derivatives
Thiourea - therapeutic use
Tryptamines - administration & dosage
Online AccessGet more information

Cover

More Information
Summary:In 30--60 minutes following their administration sodium oxybutyrate in a dose of 100 mg/kg, mexamine in a dose of 2.5 and 5 mg/kg and also gutimine in doses of 25,50 and 100 mg/kg under conditions of hypoxic hypoxia corresponding to an altitude of 10000 m produce a marked antihypoxic effect. A combination of sodium oxybutyrate in the above dose, of mexamine in amounts of 1,2.5 and 5 mg/kg and also of gutimine in doses of 25,50 and 100 mg/kg permit it in some cases to achieve potentiation of antihypoxic effects of the drugs.
ISSN:0014-8318