Side effects of non-steroidal antirheumatic agents in the lower gastrointestinal tract

Peptic gastroduodenal lesions due to nonsteroidal antiinflammatory drugs (NSAID) are well known, but not the adverse effects of these preparations in the lower GI tract. The cases of 5 patients with NSAID-induced colitis are described and the pertinent literature is reviewed, which reveals a wide sp...

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Bibliographic Details
Published inSchweizerische medizinische Wochenschrift Vol. 117; no. 40; p. 1527
Main Author Güller, R
Format Journal Article
LanguageGerman
Published Switzerland 03.10.1987
Subjects
Adult
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Colitis - chemically induced
Diclofenac - adverse effects
Female
Humans
Male
Mefenamic Acid - adverse effects
Middle Aged
Proctitis - chemically induced
Salicylates - adverse effects
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Summary:Peptic gastroduodenal lesions due to nonsteroidal antiinflammatory drugs (NSAID) are well known, but not the adverse effects of these preparations in the lower GI tract. The cases of 5 patients with NSAID-induced colitis are described and the pertinent literature is reviewed, which reveals a wide spectrum of alterations ranging from mild non-specific colitis to acute bleeding or perforation. The most important key to correct diagnosis is a careful drug history, and treatment is to discontinue the NSAID.
ISSN:0036-7672