Selected immunologic parameters and infections in children in over 1 year after completion of the treatment of acute lymphoblastic leukemia

An analysis of infection incidence within one year after completion of the treatment for the acute lymphoblastic leukemia was performed in the group of 24 children. Infections incidence was related to the selected immunological parameters, mainly T4 and T8 lymphocyte subpopulations assayed with mono...

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Published inPolski tygodnik lekarski (Warsaw, Poland : 1960) Vol. 44; no. 14; p. 320
Main Authors Rytwiński, K, Sońta-Jakimczyk, D, Sroczyńska, M, Wójcik, Z, Dzielicki, J
Format Journal Article
LanguagePolish
Published Poland 03.04.1989
Subjects
Bacterial Infections - etiology
Child
Complement C3 - immunology
Humans
Immune Tolerance - immunology
Leukocyte Count
Opportunistic Infections - etiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
T-Lymphocytes - immunology
Time Factors
Transferrin - analysis
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Summary:An analysis of infection incidence within one year after completion of the treatment for the acute lymphoblastic leukemia was performed in the group of 24 children. Infections incidence was related to the selected immunological parameters, mainly T4 and T8 lymphocyte subpopulations assayed with monoclonal antibodies. T4/T8 cells ratio (Ix) was determined. It was found that moderate decrease in the total lymphocyte count and Ix exist in children one year after completion of the treatment. This index is more significantly lower in children with more frequent infections while the absolute numbers of T4 and T8 lymphocytes are relatively increased. The obtained results suggest that no significant immunosuppression is observed in children affecting the number and the course of infections.
ISSN:0032-3756