Phosphorus-calcium metabolism and calcium-regulating hormones in endogenous hypercorticism

The authors presented the results of a study of the indices of phosphorocalcium homeostasis, metabolism of osseous tissue and calcium regulating hormones in 44 patients with Icenko-Cushing's syndrome with regard to severity of disease and expression of osteoporosis. It was shown that disturbanc...

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Bibliographic Details
Published inProblemy ėndokrinologii Vol. 32; no. 6; p. 13
Main Authors Rozhinskaia, L Ia, Ermakova, I P, Marova, E I, Bukhman, A I, Pronchenko, I A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1986
Subjects
Adolescent
Adrenocortical Hyperfunction - complications
Adrenocortical Hyperfunction - metabolism
Adult
Calcitonin - blood
Calcium - metabolism
Cushing Syndrome - metabolism
Female
Humans
Male
Middle Aged
Osteoporosis - etiology
Parathyroid Hormone - blood
Phosphorus - metabolism
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Summary:The authors presented the results of a study of the indices of phosphorocalcium homeostasis, metabolism of osseous tissue and calcium regulating hormones in 44 patients with Icenko-Cushing's syndrome with regard to severity of disease and expression of osteoporosis. It was shown that disturbances of phosphorocalcium homeostasis and an increase in the level of the parathyroid hormone were characteristic for the active stage of Icenko-Cushing's disease and were most noticeable in a severe course of disease accompanied by sharply marked osteoporosis. Hypocalcemia, hypophosphatemia, hypercalciuria, a decrease in phosphate maximum resorption and an increase in AP activity in the blood serum were revealed in this form of disease. Patients with the average gravity of disease and weakly pronounced osteoporosis were characterized by hypercalcemia and an increase in calcium intestinal absorption. Patients with the active stage of hypercorticism were characterized by hypermagnesemia. Secondary hyperparathyrosis was found in 25% of patients with the active stage of Icenko-Cushing's disease.
ISSN:0375-9660