Embryotropic action of phosalone

The study on the embryotrophic action of phosalon insecticide preparation is conducted against the background of its comprehensive and thorough hygiene-toxicologic assay. Pregnant white rats undergo treatment per os with 1/10 and 1/100 LD50 throughout the entire gravidity period. Recordings are made...

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Bibliographic Details
Published inProblemi na khigienata Vol. 2; p. 209
Main Authors Mikhaĭlova, Z, Vachkova-Petrova, R
Format Journal Article
LanguageBulgarian
Published Bulgaria 1976
Subjects
Animals
Animals, Newborn
Dose-Response Relationship, Drug
Embryo, Mammalian - drug effects
Embryo, Mammalian - enzymology
Enzyme Activation - drug effects
Female
Gestational Age
Insecticides - toxicity
Liver - drug effects
Liver - enzymology
Organothiophosphorus Compounds
Pregnancy
Rats
Teratogens
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Summary:The study on the embryotrophic action of phosalon insecticide preparation is conducted against the background of its comprehensive and thorough hygiene-toxicologic assay. Pregnant white rats undergo treatment per os with 1/10 and 1/100 LD50 throughout the entire gravidity period. Recordings are made of the quantity of corpora lutea, pre- and postimplantation lethality; the pedigree development is traced up to the end of the second postnatal month with readings being made of weight and length in the first postnatal day, presence or not of external malformations, weight increase and survival up to the end of the lactation period, day of eye cleft opening and hairing, and sex ratio. The presence of phosalon and phosalon-oxone in whole embryo homogenates is estimated. Enzyme activity of GOT, GPT, catalase, LDH, G-6-PD, RNA and DNA quantity are studied in the liver of newborns on the second postnatal day. Within 21 days of birth, the peripheral blood picture and visceral weight coefficient are also studied. Investigation of the peripheral blood picture, activity of catalase, GOT and GPT in the liver and serum, alkaline and acid phosphatase, and peroxidase in the serum is performed at the end of the second month. The results point to the presence of an embryotoxic effect at the level of the investigated hepatic indicators, detected on the 2nd day of the postnatal period, only at 1/10 LD50 dose.
ISSN:0323-9179