Evaluation of the risks of transabdominal chorionic villus sampling. 600 cases

• Published in: Journal de gynécologie, obstétrique et biologie de la reproduction Vol. 20; no. 4; p. 496
• Main Authors: Saura, R, Horovitz, J, Grison, O, Longy, M, Maugey, B, Lesesve, J F, Vergnaud, A, Roux, D
• Format: Journal Article
• Language: French
• Published: France 1991
• Subjects: Abdomen; Abortion, Spontaneous - epidemiology; Abortion, Spontaneous - etiology; Adult; Chorionic Villi Sampling - adverse effects; Chorionic Villi Sampling - methods; Chorionic Villi Sampling - standards; Chromosome Aberrations - diagnosis; Chromosome Aberrations - epidemiology; Chromosome Disorders; Evaluation Studies as Topic; Female; Genetic Testing; Humans; Pregnancy; Prenatal Diagnosis; Risk Factors; Sensitivity and Specificity
• ISSN: 0368-2315

The authors report their experience with fine needle chorionic villus sampling carried out transabdominally. Six hundred antenatal karyotype diagnoses were made using this method. The indications were: maternal age: 509 (85%), previous chromosomal abnormalities: 57 (9.5%), parental chromosomal abnormalities: 19 (3%), X chromosome linked diseases: 9 (1.5%), others: 6 (1%). The patients were divided into two groups according as to whether the test was carried out before or after 12 weeks of amenorrhea (Group 1 and Group 2). Each group was divided into two sub-groups according to whether the amniotic membranes were broken or not. The test was carried out using a 20 gauge needle under ultrasound control with a to-and-fro movement using continuous aspiration. The success rate was 98.4%. Minor complications were rare. Contractions 9 (1.5%), spotting 4 (0.6%), small haematomas 13 (2.1%), loss of amniotic fluid 4 (0.6%). The level of unintentional abortions depended on the duration of the pregnancy and whether the amniotic cavity or not was entered. In group 1 (before or at 12 weak amenorrhea) there were 2 abortions out of 124 cases (1.6%) and if the needle entered the amniotic cavity 10 out of 57 cases (17.5%). In group 2 (after 12 weeks of amenorrhea) there was no ill effect from going into the amniotic cavity to the rest of the pregnancy. The abortion rates was 6 out of 419 (1.43%). There were no false positive or negative results.