Urokinase in a premature infant: its use in a case of right atrial thrombosis secondary to catheterization of the umbilical vein

Newborns with vascular catheters must be investigated by echocardiogram for intracardiac thrombosis. We report the use of urokinase to treat an asymptomatic right atrial thrombus in a 31 weeks' gestation newborn; the thrombosis occurred after placement of a catheter in the umbilical vein. We ob...

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Bibliographic Details
Published inLa Pediatria medica e chirurgica Vol. 17; no. 3; p. 275
Main Authors Colnaghi, C, Cazzuffi, M A, Introvini, P, Fornerone, R, Sabatini, I, Borin, F, Magni, L A
Format Journal Article
LanguageItalian
Published Italy 01.05.1995
Subjects
Catheterization, Peripheral - adverse effects
Echocardiography
Gestational Age
Heart Atria - diagnostic imaging
Heart Diseases - diagnostic imaging
Heart Diseases - drug therapy
Heart Diseases - etiology
Humans
Infant, Newborn
Male
Thrombolytic Therapy - methods
Thrombosis - diagnostic imaging
Thrombosis - drug therapy
Thrombosis - etiology
Umbilical Veins
Urokinase-Type Plasminogen Activator - administration & dosage
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Summary:Newborns with vascular catheters must be investigated by echocardiogram for intracardiac thrombosis. We report the use of urokinase to treat an asymptomatic right atrial thrombus in a 31 weeks' gestation newborn; the thrombosis occurred after placement of a catheter in the umbilical vein. We obtained a safe and successful thrombolysis using urokinase 4000 U/kg/h in continuous infusion.
ISSN:0391-5387