The protective effect of monoclonal anti-idiotypic antibodies in experimental herpes infection

The protective effect of monoclonal anti-idiotypic antibodies m(anti-ID)Abs, simulating the biologic effects of human alpha interferons, were studied in male guinea pigs with genital herpes simplex. Therapeutic effect of m(anti-ID)Abs daily applied as liquid dosage form and as suppositories+ was ass...

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Bibliographic Details
Published inVoprosy virusologiĭ Vol. 40; no. 2; p. 70
Main Authors Nagieva, F G, Barkova, E P, Nikulina, V G, Krasnova, N I, Andzhaparidze, O G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.1995
Subjects
Animals
Antibodies, Anti-Idiotypic - therapeutic use
Antibodies, Monoclonal - therapeutic use
Cell Line
Cercopithecus aethiops
Cricetinae
Guinea Pigs
Herpes Simplex - prevention & control
Immunotherapy
Male
Vero Cells
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Summary:The protective effect of monoclonal anti-idiotypic antibodies m(anti-ID)Abs, simulating the biologic effects of human alpha interferons, were studied in male guinea pigs with genital herpes simplex. Therapeutic effect of m(anti-ID)Abs daily applied as liquid dosage form and as suppositories+ was assessed. Experiments demonstrated that m(anti-ID)Abs in liquid dosage form to a different measure decreased the severity of urogenital infection in guinea pigs and that m(anti-ID)Abs-25 completely prevented the development of grave infection.
ISSN:0507-4088