Effect of chronic stress during pregnancy on the functional state of the hypothalamo-hypophyseo-adrenal system in the progeny

A study was made of the effect of a chronic stress on the activity of the hypothalamo-hypophyseo-adrenal system in pregnant rats as well as on the development of its function in the progeny in postnatal ontogenesis. Experiments were made on pregnant Wistar rats and their progeny. A chronic stress in...

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Bibliographic Details
Published inProblemy ėndokrinologii Vol. 32; no. 2; p. 79
Main Authors Aliev, M G, Guseĭnova, N I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.1986
Subjects
11-Hydroxycorticosteroids - blood
Animals
Biogenic Amines - analysis
Female
Hypothalamo-Hypophyseal System - physiopathology
Hypothalamus - analysis
Pituitary Gland, Anterior - analysis
Pituitary Hormones, Anterior - analysis
Pituitary-Adrenal System - physiopathology
Pregnancy
Pregnancy Complications - physiopathology
Prenatal Exposure Delayed Effects
Rats
Rats, Inbred Strains
Stress, Physiological - physiopathology
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Summary:A study was made of the effect of a chronic stress on the activity of the hypothalamo-hypophyseo-adrenal system in pregnant rats as well as on the development of its function in the progeny in postnatal ontogenesis. Experiments were made on pregnant Wistar rats and their progeny. A chronic stress in the 2nd half of pregnancy has been shown to have a detrimental effect on function of the hypothalamo-hypophyseo-adrenal system not only of pregnant animals but also of their progeny, particularly in early periods of postnatal development. In prenatally stressed animals a delay in the development of the monoaminergic system of the hypothalamus was observed which, in its turn, had an effect on the level of the main adenohypophyseal hormones (ACTH, STH and prolactin).
ISSN:0375-9660