Spatial structure of a vasoactive peptide--a fibrin fragment

Empirical energy calculations were used to determine all low-energy conformations of vasoactive pentapeptide Ala-Arg-Pro-Ala-Lys, thereby three most stable conformations were distinguished. Biological testing of conformationally restricted analogs allowed to delineate the most probable "biologi...

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Bibliographic Details
Published inBioorganicheskaia khimiia Vol. 9; no. 1; p. 33
Main Authors Nikolaĭchik, V V, Galaktionov, S G, Tseĭtlin, V M, Mikhneva, L M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1983
Subjects
Fibrin Fibrinogen Degradation Products
Models, Molecular
Oligopeptides
Protein Conformation
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Summary:Empirical energy calculations were used to determine all low-energy conformations of vasoactive pentapeptide Ala-Arg-Pro-Ala-Lys, thereby three most stable conformations were distinguished. Biological testing of conformationally restricted analogs allowed to delineate the most probable "biologically active" conformation of the molecule.
ISSN:0132-3423