Glucose intolerance in familial combined hyperlipidaemia. EUFAM study group

• Published in: European journal of clinical investigation Vol. 28; no. 1; pp. 24 - 32
• Main Authors: Vakkilainen, J, Porkka, K V, Nuotio, I, Pajukanta, P, Suurinkeroinen, L, Ylitalo, K, Viikari, J S, Ehnholm, C, Taskinen, M R
• Format: Journal Article
• Language: English
• Published: England 01.01.1998
• Subjects: Adolescent; Adult; Aged; Cohort Studies; Female; Glucose Intolerance - complications; Glucose Intolerance - epidemiology; Glucose Intolerance - genetics; Glucose Tolerance Test; Humans; Hyperlipidemia, Familial Combined - complications; Hyperlipidemia, Familial Combined - epidemiology; Hyperlipidemia, Familial Combined - genetics; Insulin Resistance - genetics; Male; Middle Aged; Prevalence
• ISSN: 0014-2972

Familial combined hyperlipidaemia (FCHL) is a common hereditary disorder. Hypertriglyceridaemia is associated with glucose intolerance and insulin resistance. To study glucose tolerance in FCHL patients with different lipid phenotypes [hypercholesterolaemia (IIA), mixed hyperlipidaemia (IIB), hypertriglyceridaemia (IV)], we investigated 253 family members and 92 spouses arising from 33 well-defined Finnish FCHL pedigrees. In oral glucose tolerance tests the affected family members had higher values for glucose area under the curve than did non-affected family members [673+/-127 min mmolL(-1), 754+/-145 min mmol L(-1), 846+/-180 min mmol L(-1) and 838+/-183 min mmol L(-1) for phenotypes normal, IIA, IIB and IV respectively; P < 0.001 after adjustment for body mass index, waist circumference and age]. Impaired glucose tolerance and diabetes were more common among affected than non-affected family members (prevalences of normal glucose tolerance 94.0%, 80.0%, 54.3% and 58.5% for phenotypes normal, IIA, IIB and IV). Affected FCHL family members were more glucose intolerant than non-affected family members. In men, this disturbance was not related to lipid phenotype nor was it explained by obesity.