Effects of buspirone and buspirone-like 1-A-agonists of serotonin on the level of systemic blood pressure

Experiments on anaesthetized rats showed that buspirone, its structural analogies (ipsapirone, campirone and levopirone) and active metabolite 1-(2-pyrimidinyl)-piperazine (0.1-30 mg/kg i.v.) produced bradycardia, hyperpnea and changed the arterial pressure level. Arterial pressure either increased...

Full description

Saved in:
Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 112; no. 7; p. 62
Main Authors Komissarov, I V, Mamonov, A V, Filippov, I T
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1991
Subjects
Animals
Anti-Anxiety Agents - pharmacology
Blood Pressure - drug effects
Buspirone - analogs & derivatives
Buspirone - pharmacology
Muscle, Smooth, Vascular - drug effects
Rats
Receptors, Serotonin - drug effects
Online AccessGet more information

Cover

More Information
Summary:Experiments on anaesthetized rats showed that buspirone, its structural analogies (ipsapirone, campirone and levopirone) and active metabolite 1-(2-pyrimidinyl)-piperazine (0.1-30 mg/kg i.v.) produced bradycardia, hyperpnea and changed the arterial pressure level. Arterial pressure either increased or decreased that was determined by its initial level. The hypotension produced by all these drugs was of a central origin and mediated by hydroxytryptamine-1A-receptors. The pressor response resulted from activation of predominantly hydroxytryptamine-2-receptors of vascular smooth muscles.
ISSN:0365-9615