An experimental study of tumor-tropic properties of radionuclide-labeled liposomes

The paper is concerned with the results of experimental investigations to develop methods for obtaining 99mTc and 67Ga-labeled liposomes, possessing tumor-tropic properties. Sphingomyelin vesiculae, labeled with 67Ga with the help of bifunctional chelates, were shown to possess a high level of hyper...

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Bibliographic Details
Published inMeditsinskaia radiologiia Vol. 36; no. 9; p. 39
Main Authors Kostenikov, N A, Fadeev, N P, Serzhanina, V A, Korsakova, L N, Rozenberg, O A
Format Journal Article
LanguageRussian
Published Russia (Federation) 1991
Subjects
Animals
Gallium Radioisotopes - administration & dosage
Liposomes
Lymphoma, Non-Hodgkin - diagnostic imaging
Male
Radionuclide Imaging
Rats
Sarcoma, Experimental - diagnostic imaging
Technetium - administration & dosage
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Summary:The paper is concerned with the results of experimental investigations to develop methods for obtaining 99mTc and 67Ga-labeled liposomes, possessing tumor-tropic properties. Sphingomyelin vesiculae, labeled with 67Ga with the help of bifunctional chelates, were shown to possess a high level of hyperfixation. A study of biodistribution of these liposomes in rats with Plis lymphosarcoma showed that the level of accumulation of 67Ga-liposomes was enough to obtain a clear scintigraphic tumor image.
ISSN:0025-8334