Effect of a limitation of the food ration on macrophage functional activity and angiogenesis in mice with metastasizing tumors

In mice with metastasizing tumors that received a reduced (by 30-40%) daily ration, suppression of neovascularization processes and normalization of macrophage function were recorded: activity of macrophages in the area of the metastatic growth increased, while activity of macrophages suppressing T-...

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Bibliographic Details
Published inVoprosy pitaniia no. 6; p. 48
Main Authors Sopotsinskaia, E B, Umanskiĭ, V Iu, Lisniak, I A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1988
Subjects
Animals
Female
Immune Tolerance
Immunity, Innate
Lung Neoplasms - diet therapy
Lung Neoplasms - immunology
Lung Neoplasms - secondary
Macrophages - enzymology
Macrophages - immunology
Mice
Mice, Inbred C57BL
Neoplasm Transplantation
Neovascularization, Pathologic
Pulmonary Alveoli - immunology
Skin - blood supply
Spleen - immunology
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Summary:In mice with metastasizing tumors that received a reduced (by 30-40%) daily ration, suppression of neovascularization processes and normalization of macrophage function were recorded: activity of macrophages in the area of the metastatic growth increased, while activity of macrophages suppressing T-lymphocytes in the spleen was decreased. It has been suggested that these effects play a role in the phenomenon observed by the authors--suppression of the metastatic processes in the test mice kept on a reduced food ration.
ISSN:0042-8833