Comparative evaluation of the anti-arrhythmia effectiveness of mezotrin and izoptin

• Published in: Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR Vol. 9; no. 2; p. 40
• Main Authors: Dzhishambaev, E D, Ivanova, L A, Bugriĭ, E M, Mazur, N A, Pavlova, T S
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1986
• Subjects: Adolescent; Adult; Anti-Arrhythmia Agents - adverse effects; Anti-Arrhythmia Agents - pharmacology; Anti-Arrhythmia Agents - therapeutic use; Arrhythmias, Cardiac - drug therapy; Arrhythmias, Cardiac - physiopathology; Clinical Trials as Topic; Diamines - adverse effects; Diamines - pharmacology; Diamines - therapeutic use; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate - drug effects; Humans; Middle Aged; Monitoring, Physiologic; Verapamil - adverse effects; Verapamil - pharmacology; Verapamil - therapeutic use
• ISSN: 0201-7369

Isoptin and mesotrin (a new hypothetical calcium antagonist) were administered to 30 patients with frequent and persistent premature beats (22 patients with premature ventricular beats and 8 patients with premature supraventricular beats). The antiarrhythmic activity of mesotrin was nearly twice as high as that of isoptin, the antiarrhythmic effect being achieved in 63 and 33% of patients, respectively, which was especially distinct in ventricular rhythm disturbances (64 and 27%, respectively). The effective dose of mesotrin was approximately 2.5 mg/kg. Isoptin produced the greatest effect on atrio-ventricular conduction, while mesotrin to a great extent influenced atrial and ventricular conduction. Certain side effects of mesotrin were observed, consisting in slight euphoria, ventigo and heavyheadedness subduing spontaneously 10-15 minutes after administering the drug. Care should be taken when administering the drug to patients with sick sinus syndrome because of the possibility of its arrest.