Hyperinsulinism probably caused by diffuse pancreatic hyperplasia

A case history of a two years seven months old boy with hyperinsulinism and marked psychomotor retardation is presented. In this patient, biochemical analysis revealed persistent hypoglycemia. Basal insulin levels (RIA) were consistently superior to 10 mU/ml. and were higher than would be expected f...

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Bibliographic Details
Published inAnales españoles de pediatría Vol. 13; no. 11; p. 1017
Main Authors Oliete García, F, Herrera Andújar, P, Pérez Carmona, N J, Balboa de Paz, F
Format Journal Article
LanguageSpanish
Published Spain 01.11.1980
Subjects
Child, Preschool
Diazoxide - therapeutic use
Humans
Hyperinsulinism - drug therapy
Hyperinsulinism - etiology
Hyperplasia
Hypoglycemia - etiology
Male
Pancreas - pathology
Psychomotor Disorders - etiology
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Summary:A case history of a two years seven months old boy with hyperinsulinism and marked psychomotor retardation is presented. In this patient, biochemical analysis revealed persistent hypoglycemia. Basal insulin levels (RIA) were consistently superior to 10 mU/ml. and were higher than would be expected from the child's glycemias. Angiographic study of the celiac trunk revealed diffuse pancreatic enlargement. Therapy was initiated with oral diazoxide normalizing and stabilizing the patient's glycemia. The importance of an early diagnosis of this condition and the necessary biochemical analyses involved are discussed as well as the use of diazoxide in the medical treatment of hypoglycemia.
ISSN:0302-4342