Biosynthesis of immunoreactive luteinizing hormone in the central nervous system of rats

The authors detected the biosynthesis in vitro of the immunoreactive LH in the pineal gland and hypothalamus of rats using a specific immunosorbent to LH. The synthesis of this hormone was undetectable in the thalamus, striate body and in the cerebral cortex. Puromycin decreased the synthesis of the...

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Bibliographic Details
Published inProblemy ėndokrinologii Vol. 31; no. 1; p. 44
Main Authors Nabatchikova, N A, Krivosheev, O G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1985
Subjects
Animals
Culture Media
Drug Interactions
Gonadotropin-Releasing Hormone - pharmacology
Hormones - pharmacology
Hormones, Ectopic - biosynthesis
Hypothalamus - metabolism
Immunosorbent Techniques
In Vitro Techniques
Luteinizing Hormone - antagonists & inhibitors
Luteinizing Hormone - biosynthesis
Pineal Gland - metabolism
Puromycin - pharmacology
Rats
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Summary:The authors detected the biosynthesis in vitro of the immunoreactive LH in the pineal gland and hypothalamus of rats using a specific immunosorbent to LH. The synthesis of this hormone was undetectable in the thalamus, striate body and in the cerebral cortex. Puromycin decreased the synthesis of the hormone in the pineal gland and hypothalamus by 40% and 60% respectively. LH-RH stimulated the biosynthesis of the immunoreactive LH in the pineal gland. It was assumed that LH-producing cells are present in the pineal gland and hypothalamus of rats.
ISSN:0375-9660