The relationship of PSA to age and prostatic volume in patients with benign prostatic hypertrophy

Prostate specific antigen (PSA) is the most useful market for the diagnosis, staging and monitoring of prostate cancer. However, the effect of benign prostate hyperplasia on PSA levels is less well known. It has been reported that 20-45% of all adult males with BPH have PSA values over the normal ra...

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Bibliographic Details
Published inActas urologicas españolas Vol. 19; no. 3; p. 181
Main Authors Sánchez Sánchez, E, Paez Borda, A, Herrero Payo, A, Ruiz Rubio, J L, Acebal Lucía, J, Berenguer Sánchez, A
Format Journal Article
LanguageSpanish
Published Spain 01.03.1995
Subjects
Aged
Aged, 80 and over
Aging - blood
Aging - pathology
Humans
Linear Models
Male
Middle Aged
Organ Size
Prostate - diagnostic imaging
Prostate - pathology
Prostate-Specific Antigen - blood
Prostatectomy
Prostatic Hyperplasia - diagnosis
Prostatic Hyperplasia - surgery
Retrospective Studies
Sensitivity and Specificity
Ultrasonography
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Summary:Prostate specific antigen (PSA) is the most useful market for the diagnosis, staging and monitoring of prostate cancer. However, the effect of benign prostate hyperplasia on PSA levels is less well known. It has been reported that 20-45% of all adult males with BPH have PSA values over the normal range. To study this confounding factor we have analyzed the likely relationships between monoclonal PSA, age and prostate size as determined by ultrasound, in our series of 163 patients with BPH undergoing adenomectomy. Within the studied factors, the most conditioning parameter of PSA variability was prostate size. The correlation coefficient (r) was 0.61, with the determination coefficient (r2) being 0.037 (p < 0.001). Age correlation, although less important (r = 0.31), was statistically significant. Both variables were independent and resulted jointly in a correlation coefficient of 0.64. Also included is the mathematical formula used in our series to correlate PSA with age and prostate volume. Its application could mean an increased specificity of this tumoral marker.
ISSN:0210-4806