Cardioprotective properties of a 1,4-dihydropyridine derivative, glutapyrone, in deep hypothermia

Effect of the derivative of 1,4-dihydropyridine-glutapyron on the activity of Ca2(+)-ATPase, lipid peroxidation and formation of the high-energy phosphate in the myocardium under deep hypothermia was investigated. Analysis of chemiluminescence parameters and changes of malondialdehyde production as...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 108; no. 11; p. 558
Main Authors Utno, L Ia, Lipsberga, Z E, Silova, A A, Girgensone, M Ia, Bisenieks, E A, Dubur, G Ia
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1989
Subjects
Animals
Antioxidants - pharmacology
Calcium-Transporting ATPases - metabolism
Dihydropyridines - pharmacology
Free Radicals
Heart - drug effects
Hypothermia, Induced
Lipid Peroxidation
Male
Mitochondria, Heart - metabolism
Myocardium - metabolism
Rats
Rats, Inbred Strains
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Summary:Effect of the derivative of 1,4-dihydropyridine-glutapyron on the activity of Ca2(+)-ATPase, lipid peroxidation and formation of the high-energy phosphate in the myocardium under deep hypothermia was investigated. Analysis of chemiluminescence parameters and changes of malondialdehyde production as a measure of peroxidation has shown high antioxidant activity of glutapyron under deep hypothermia. The inhibition of peroxidation by glutapyron takes place in the lipids of erythrocyte and heart mitochondrial membranes. Due to antioxidant activity glutapyron is able to inhibit initiation of free radical lipid oxidation, to stabilize membrane structure and to preserve function of membrane integrated proteins. In the aggregate these actins promote activity maintenance of high-energy phosphate production and transport reactions in heart under deep hypothermia.
ISSN:0365-9615