Microorganisms synthesizing enzymes with thrombolytic action

The literary and experimental data obtained by the authors concerning the ability of various microorganisms to synthesize exoproteases lysing the thrombi of human blood are presented in the article. Various methods of enhancing the thrombolytic activity of microorganisms cultures, the properties of...

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Bibliographic Details
Published inNauchnye doklady vysshei shkoly. Biologicheskie nauki no. 9; p. 136
Main Authors Demina, N S, Lysenko, S V
Format Journal Article
LanguageRussian
Published Russia (Federation) 1991
Subjects
Bacteria - enzymology
Bacteria - growth & development
Culture Media
Exopeptidases
Fibrin - metabolism
Fibrinogen - metabolism
Fibrinolytic Agents - metabolism
Fibrinolytic Agents - therapeutic use
Fungi - enzymology
Fungi - growth & development
Humans
Peptide Hydrolases - biosynthesis
Peptide Hydrolases - therapeutic use
Thrombosis - drug therapy
Thrombosis - metabolism
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Summary:The literary and experimental data obtained by the authors concerning the ability of various microorganisms to synthesize exoproteases lysing the thrombi of human blood are presented in the article. Various methods of enhancing the thrombolytic activity of microorganisms cultures, the properties of some isolated and purified preparations, methods of enlarging the specificity of the enzymes to fibrin and of reduction of their toxicity are considered.
ISSN:0470-4606