Effect of the sympatholytic pirroxan on catecholamine excretion in experimental tetanus

Excretion of catecholamines and vanilylmandelic acid was studied in rabbits with tetanic intoxication. It was found that catecholamine excretion increases up to 173% in the initial stages of the disease and falls to 51% at the height of the disease whereas excretion of vanilylmandelic acid progressi...

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Bibliographic Details
Published inFarmakologiia i toksikologiia Vol. 44; no. 1; p. 115
Main Authors Aleksevich, Ia I, Kun, N D
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1981
Subjects
Animals
Catecholamines - urine
Dioxanes - therapeutic use
Dioxins - therapeutic use
Diuresis
Pyrrolidines - therapeutic use
Rabbits
Tetanus - drug therapy
Tetanus - urine
Vanilmandelic Acid - urine
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Summary:Excretion of catecholamines and vanilylmandelic acid was studied in rabbits with tetanic intoxication. It was found that catecholamine excretion increases up to 173% in the initial stages of the disease and falls to 51% at the height of the disease whereas excretion of vanilylmandelic acid progressively decreases down to 40% against normal. Pirroxan (10 mg/kg a day) reduces excretion of catecholamines and vanilylmandelic acid by three times, concurrently producing a definite cholinolytic effect.
ISSN:0014-8318