Effect of oxaloacetic acid on hydrogen-calcium metabolism in mitochondria

It has been shown by using o-phthalic acid--a concurrent inhibitor of the transport of oxalacetic acid in mitochondria that the effect of the latter on the mechanism of 2H+/Ca2+-metabolism is realized at the inner side of the inner mitochondrial membrane. Oxalacetic acid was shown to induce not only...

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Bibliographic Details
Published inBiofizika Vol. 32; no. 3; p. 454
Main Authors Asrarov, M I, Gagel'gans, A I, Tashmukhamedov, B A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1987
Subjects
Animals
Binding, Competitive
Biological Transport
Calcium - metabolism
Hydrogen - metabolism
In Vitro Techniques
Intracellular Membranes - metabolism
Kinetics
Mitochondria, Liver - drug effects
Mitochondria, Liver - metabolism
Oxaloacetates - metabolism
Oxaloacetates - pharmacology
Permeability
Phthalic Acids - pharmacology
Rats
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Summary:It has been shown by using o-phthalic acid--a concurrent inhibitor of the transport of oxalacetic acid in mitochondria that the effect of the latter on the mechanism of 2H+/Ca2+-metabolism is realized at the inner side of the inner mitochondrial membrane. Oxalacetic acid was shown to induce not only the release of Ca2+ ions but also those of strontium and manganese accumulated in the mitochondria (100-150 nmol/mg of protein). Mechanism of the effect of oxalacetic acid on permeability of the mitochondria membranes are discussed.
ISSN:0006-3029