The effect of alpha-tocopherol on pulmonary surfactants

Tocopherol deficiency in the rat organism stimulates activation of lipid peroxidation: the content of hydroperoxides in blood and surfactants of lungs tends to increase, the superweak glow of surfactant lipids enhances. In this case the surface activity of lung surfactants is lower than in the contr...

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Bibliographic Details
Published inUkrainskij biohimičeskij žurnal Vol. 60; no. 6; p. 88
Main Authors Berezovskiĭ, V A, Iakovleva, O A, Gorchakov, V Iu, Mukalov, I O, Khasabova, I A
Format Journal Article
LanguageRussian
Published Ukraine 01.11.1988
Subjects
Animals
Lipid Peroxidation - drug effects
Luminescence
Male
Pulmonary Surfactants - metabolism
Rats
Rats, Inbred Strains
Vitamin E - pharmacology
Vitamin E Deficiency - metabolism
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Summary:Tocopherol deficiency in the rat organism stimulates activation of lipid peroxidation: the content of hydroperoxides in blood and surfactants of lungs tends to increase, the superweak glow of surfactant lipids enhances. In this case the surface activity of lung surfactants is lower than in the control. It also gets lower in hypervitaminosis rats. The data obtained may be used for development of approaches to the tocopherol (antioxidant) correlation of the lung surfactant system functioning.
ISSN:0201-8470