Fibrinolysis defects in patients with recurrent thromboses

In 53 patients suffering from recurrent thrombosis various hemostaseological parameters were investigated. In 91 per cent of the patients spontaneous fibrinolytic activity was decreased. Decreased or lacking activity of the fibrinolytic system following venous occlusion was found in 48 per cent. In...

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Bibliographic Details
Published inFolia haematologica (Leipzig, Germany : 1928) Vol. 113; no. 1-2; p. 208
Main Authors Nagy, I, Losonczy, H
Format Journal Article
LanguageGerman
Published Germany 1986
Subjects
alpha-Macroglobulins - analysis
Antithrombin III Deficiency
Fibrinolysis
Humans
Recurrence
Thrombosis - blood
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Summary:In 53 patients suffering from recurrent thrombosis various hemostaseological parameters were investigated. In 91 per cent of the patients spontaneous fibrinolytic activity was decreased. Decreased or lacking activity of the fibrinolytic system following venous occlusion was found in 48 per cent. In most cases, the concentration of alpha 2-macroglobulin was reduced. This was most pronounced in patients with antithrombin III deficiency. In nearly all cases the concentration of alpha 2-antiplasmin was enhanced. Prospective long-term studies on the importance of defective fibrinolysis are required.
ISSN:0323-4347