Relative biological effectiveness (RBE) of neutrons produced by 50 MeV deuterons and by 34, 45, 65 and 75 MeV protons

RBE of p(34) + Be, p(45) + Be, p(65), + Be, p(75) + Be and d(50) + Be neutron beams produced at the cyclotron "Cyclone" of Louvain-la-Neuve were measured. The biological criterion was the regeneration of the crypts of the intestinal mucosa (50 regenerated crypts per circumference) after ab...

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Bibliographic Details
Published inComptes rendus des seances de la Societe de biologie et de ses filiales Vol. 181; no. 1; p. 78
Main Authors Beauduin, M, Gueulette, J, De Coster, B M, Octave-Prignot, M, Vynckier, S, Wambersie, A
Format Journal Article
LanguageFrench
Published France 1987
Subjects
Activation Analysis
Animals
Deuterium - therapeutic use
Intestinal Mucosa - physiology
Intestinal Mucosa - radiation effects
Mice
Neutron Activation Analysis
Protons
Regeneration
Relative Biological Effectiveness
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Summary:RBE of p(34) + Be, p(45) + Be, p(65), + Be, p(75) + Be and d(50) + Be neutron beams produced at the cyclotron "Cyclone" of Louvain-la-Neuve were measured. The biological criterion was the regeneration of the crypts of the intestinal mucosa (50 regenerated crypts per circumference) after abdominal irradiation in mice. Taking the p(65) + Be neutrons as reference, RBE values were found equal to 1.12, 1.07, 1.00 (Ref.), 0.96 and 1.02 respectively. These results are consistent with those published for cell lethality in vitro. However, the RBE variation is smaller than this previously obtained in the laboratory for growth inhibition in Vicia faba.
ISSN:0037-9026