The prognostic significance of pre-existing lymphocytotoxic antibodies in cadaveric kidney allografts with a negative specific crossmatch

The paper presents the results obtained on preexisting lymphocytotoxic antibodies in 110 patients with the use of cryopreserved donor lymphocytes. Preexisting antibodies (PA) are shown to display in 52% of primary patients in the nephrological department. Follow-up measurements gave evidence on PA l...

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Bibliographic Details
Published inUrologiia i nefrologiia no. 4; p. 30
Main Authors Kharlamova, L A, Zemlianitskaia, T L, Makhlin, N V, Iankovoĭ
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1993
Subjects
Antilymphocyte Serum - blood
Cadaver
Graft Rejection - immunology
Graft Survival - immunology
Histocompatibility Testing
HLA Antigens - blood
Humans
Kidney Transplantation - immunology
Prognosis
Time Factors
Tissue Donors
Transplantation, Homologous
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Summary:The paper presents the results obtained on preexisting lymphocytotoxic antibodies in 110 patients with the use of cryopreserved donor lymphocytes. Preexisting antibodies (PA) are shown to display in 52% of primary patients in the nephrological department. Follow-up measurements gave evidence on PA levels fluctuations following an undulating form. The analysis of the transplants 3-month survival in the negative cross-match indicated a better prognosis in those patients who showed antibodies to none of the donors. The presence of lymphocytotoxic reactions even of nondonor specificity, on the contrary, made the prognosis much worse.
ISSN:0042-1154