Plasminogen tissue activator and plasminogen tissue inhibitor in type II diabetes

The aim of study was the evaluation of tissue plasminogen activator (t-PA) and its inhibitor (PAI-1) in the II type diabetes on the base of the common fibrinolytic system tests as euglobulin lysis time (ELT) and the concentration of fibrin/fibrinogen products (FDP). The studies were performed in 21...

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Published inPolski merkuriusz lekarski Vol. 2; no. 7; p. 24
Main Authors Rość, D, Drewniak, W, Kotschy, M, Graczykowska-Koczorowska, A, Raukuć, D
Format Journal Article
LanguagePolish
Published Poland 01.01.1997
Subjects
Adult
Aged
Diabetes Mellitus, Type 2 - physiopathology
Fibrinolysis - physiology
Humans
Middle Aged
Plasminogen Inactivators - physiology
Tissue Plasminogen Activator - physiology
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Summary:The aim of study was the evaluation of tissue plasminogen activator (t-PA) and its inhibitor (PAI-1) in the II type diabetes on the base of the common fibrinolytic system tests as euglobulin lysis time (ELT) and the concentration of fibrin/fibrinogen products (FDP). The studies were performed in 21 outpatients suffering of II type diabetes aged 38-65 (median 56.0) years treated with diet and sulphonylcarbamide derivates. The control group contained 18 healthy persons aged 33-65 (median 42.0) years. In the blood the following determinations were performed: antigen of t-PA and PAI-1, ELT and FDP. In the blood of patients with II type diabetes increased. t-PA Ag and PAI-1 Ag concentrations were observed.
ISSN:1426-9686