The luliberin test as a criterion for assessing the prospect of stimulating ovulation with pergonal

Differentiated clinico-hormonal investigation using diagnostic LH-RH testing made it possible to reveal various conditions of patients with hypogonadotropic amenorrhea. The expression of clinical signs of hypoestrogenemia corresponded to a degree of hormonal insufficiency. The investigation permitte...

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Bibliographic Details
Published inProblemy ėndokrinologii Vol. 36; no. 6; p. 40
Main Authors Manuilova, I A, Nazarenko, T A, Mullabaeva, S M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1990
Subjects
Adult
Amenorrhea - blood
Amenorrhea - diagnosis
Amenorrhea - drug therapy
Drug Evaluation
Estradiol - blood
Female
Follicle Stimulating Hormone - blood
Gonadotropin-Releasing Hormone
Humans
Hypogonadism - blood
Hypogonadism - diagnosis
Hypogonadism - drug therapy
Luteinizing Hormone - blood
Menotropins - therapeutic use
Ovulation Induction - methods
Retrospective Studies
Time Factors
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Summary:Differentiated clinico-hormonal investigation using diagnostic LH-RH testing made it possible to reveal various conditions of patients with hypogonadotropic amenorrhea. The expression of clinical signs of hypoestrogenemia corresponded to a degree of hormonal insufficiency. The investigation permitted the evaluation of the prospects of perganol-stimulated ovulation and a choice of an optimum initial drug dose. Patients with moderate estrogenic insufficiency responding positively to LH-RH, were shown promising for perganol therapy. Pregnancy was noted in 86.4%, the initial drug dose was 2-3 ampules per day. In negative LH-RH testing pregnancy was noted in 12% of the patients only. The stimulation of ovulation in such patients should be started with a daily dose of 4-5 ampules of pergonal.
ISSN:0375-9660