The fertility protein factor and congenital developmental defects

Protein factor of fertility (PFF) has been measured in seminal plasma by immunodiffusion method with sensitivity about 2 mg/L. It has been found that normal level of PFF was from 16 to 256 mg/L, on the average 45.9 mg/L. Family (husband and wife) has been studied in the genetic laboratory by traditi...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 106; no. 12; p. 714
Main Authors Tatarinov, Iu S, Posiseeva, L V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.12.1988
Subjects
Congenital Abnormalities - etiology
Congenital Abnormalities - genetics
Fertility
Humans
Immunodiffusion
Male
Proteins - analysis
Reference Values
Semen - analysis
Terminology as Topic
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Summary:Protein factor of fertility (PFF) has been measured in seminal plasma by immunodiffusion method with sensitivity about 2 mg/L. It has been found that normal level of PFF was from 16 to 256 mg/L, on the average 45.9 mg/L. Family (husband and wife) has been studied in the genetic laboratory by traditional methods. It has been shown that there is the correlation between low PFF levels in seminal plasma (on the average 15.0 mg/L, i.e. from 2 to 64 mg/L) and several developmental defects of fetus. There were anencephalus, hydrocephalus, spina bifida and other morphological defects (coefficient correlation was P less than 0.01). The biological role of PFF in human developmental defects is discussed.
ISSN:0365-9615