Steroid hormone receptors and cellular proliferative activity following the short-term use of tamoxifen and chlorotrianisene in breast cancer

The content of estrogen receptors (ER), progesterone receptors (PR), the proliferative pool level in the tumour tissue were investigated in 6 patients with the disseminated breast tumour before and after 9-day treatment with tamoxifen and chlorotrianisene for intensification of the effect of cytosta...

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Bibliographic Details
Published inEksperimentalʹnaja onkologija Vol. 7; no. 5; p. 66
Main Authors Vyshinskaia, G V, Murav'eva, N I, Shelsputina, Z F, Kuz'mina, Z V, Nikolaeva, T G
Format Journal Article
LanguageRussian
Published Ukraine 1985
Subjects
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast Neoplasms - analysis
Breast Neoplasms - drug therapy
Cell Transformation, Neoplastic - drug effects
Chlorotrianisene - therapeutic use
DNA, Neoplasm - biosynthesis
Female
Humans
Middle Aged
Receptors, Estrogen - analysis
Receptors, Estrogen - drug effects
Receptors, Progesterone - analysis
Receptors, Progesterone - drug effects
Tamoxifen - therapeutic use
Time Factors
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Summary:The content of estrogen receptors (ER), progesterone receptors (PR), the proliferative pool level in the tumour tissue were investigated in 6 patients with the disseminated breast tumour before and after 9-day treatment with tamoxifen and chlorotrianisene for intensification of the effect of cytostatic preparations. A significant increase of the DNA synthesis intensity and proliferative pool value is observed in ER+ tumours of 2 patients. An increase of the PR level in tumour biopsies was registered in 2 patients. A decrease of the ER+ level was detected in ER+ tumours in all three patients.
ISSN:0204-3564