Changes in the blood-testis barrier as a result of streptococcal sensitization

Permeability of the histo-hematic barrier in the guinea pig and mouse testes immunized with streptococci has been studied radiometrically and luminescent microscopically with application of labelled bovine serum albumin, human gamma-globulin and blue dye preparations. The permeability of the hemato-...

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Bibliographic Details
Published inArkhiv anatomii, gistologii i embriologii Vol. 80; no. 5; p. 98
Main Authors Ogurtsov, R P, Zubzhitskiĭ, Iu N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1981
Subjects
Animals
Antigens, Bacterial - administration & dosage
Autoantibodies
Blood-Testis Barrier
Freund's Adjuvant - administration & dosage
gamma-Globulins - metabolism
Guinea Pigs
Male
Mice
Mice, Inbred Strains
Permeability
Serum Albumin, Bovine - metabolism
Streptococcus - immunology
Testis - immunology
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Summary:Permeability of the histo-hematic barrier in the guinea pig and mouse testes immunized with streptococci has been studied radiometrically and luminescent microscopically with application of labelled bovine serum albumin, human gamma-globulin and blue dye preparations. The permeability of the hemato-testicular barrier increases on the 7th--30th day after immunization. Test-preparations penetrate from the vessels of the intercanalicular connective tissue layers through the membrane of the convoluted tubules. The testicular autoantigen is revealed in blood. The disturbance in permeability of the hemato-testicular barrier precedes or coincides in time with the developing destruction of the testicular spermatogenic elements.
ISSN:0004-1947