Effect of triterpene glycosides on the stability of bilayer lipid membranes, containing different sterols

Low concentrations of triterpene glycosides: holothurin A, stichoposide A and cauloside C sharply change the stability of bilayer lipid-sterine membranes. The glycosides activity decreases in the line: holothurin A, stichoposide A, cauloside C. The effective doses of glycosides are to a great extent...

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Bibliographic Details
Published inBiofizika Vol. 27; no. 5; p. 827
Main Authors Popov, A M, Rovin, Iu G, Anisimov, M M, Likhatskaia, G N, Strigina, L I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.1982
Subjects
Drug Stability
Glycosides
Holothurin - analogs & derivatives
Kinetics
Lipid Bilayers
Oleanolic Acid - analogs & derivatives
Sapogenins
Saponins
Structure-Activity Relationship
Triterpenes
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Summary:Low concentrations of triterpene glycosides: holothurin A, stichoposide A and cauloside C sharply change the stability of bilayer lipid-sterine membranes. The glycosides activity decreases in the line: holothurin A, stichoposide A, cauloside C. The effective doses of glycosides are to a great extent determined by structural peculiarities of sterines which compose the films. A correlation was observed between the effect of triterpene glycosides on the stability of model bilayer membranes and their physiological activity. The model lipid-sterine membranes can be used in the primary screening of triterpene glycosides to estimate their physiological activity.
ISSN:0006-3029