The effect of dalargin on the course of experimental cardiac arrhythmias

• Published in: Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 57; no. 2; p. 24
• Main Authors: Grekova, T I, Reznikov, K M, Vinokurova, O V, Kireeva, A A, Taratinova, T I, Nikolaevskiĭ, V A, Shchetinkina, N A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.03.1994
• Subjects: Aconitine; Animals; Anti-Arrhythmia Agents - therapeutic use; Arrhythmias, Cardiac - chemically induced; Arrhythmias, Cardiac - drug therapy; Arrhythmias, Cardiac - physiopathology; Calcium Chloride; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Enkephalin, Leucine-2-Alanine - analogs & derivatives; Enkephalin, Leucine-2-Alanine - therapeutic use; Hemodynamics - drug effects; In Vitro Techniques; Lidocaine - therapeutic use; Morphine - therapeutic use; Rats; Rats, Wistar; Ventricular Fibrillation - drug therapy; Ventricular Fibrillation - etiology; Ventricular Fibrillation - physiopathology

Five models of arrhythmias (aconitine-, calcium chloride- and low-sodium-induced models on rats, coronary artery ligation and reperfusion in dogs) were used to study the antiarrhythmic and antifibrillatory effects. The latters were not inferior to those shown by the well-known antiarrhythmics. The m...