The effect of dalargin on the course of experimental cardiac arrhythmias

Five models of arrhythmias (aconitine-, calcium chloride- and low-sodium-induced models on rats, coronary artery ligation and reperfusion in dogs) were used to study the antiarrhythmic and antifibrillatory effects. The latters were not inferior to those shown by the well-known antiarrhythmics. The m...

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Bibliographic Details
Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 57; no. 2; p. 24
Main Authors Grekova, T I, Reznikov, K M, Vinokurova, O V, Kireeva, A A, Taratinova, T I, Nikolaevskiĭ, V A, Shchetinkina, N A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.1994
Subjects
Aconitine
Animals
Anti-Arrhythmia Agents - therapeutic use
Arrhythmias, Cardiac - chemically induced
Arrhythmias, Cardiac - drug therapy
Arrhythmias, Cardiac - physiopathology
Calcium Chloride
Disease Models, Animal
Dogs
Drug Evaluation, Preclinical
Enkephalin, Leucine-2-Alanine - analogs & derivatives
Enkephalin, Leucine-2-Alanine - therapeutic use
Hemodynamics - drug effects
In Vitro Techniques
Lidocaine - therapeutic use
Morphine - therapeutic use
Rats
Rats, Wistar
Ventricular Fibrillation - drug therapy
Ventricular Fibrillation - etiology
Ventricular Fibrillation - physiopathology
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Summary:Five models of arrhythmias (aconitine-, calcium chloride- and low-sodium-induced models on rats, coronary artery ligation and reperfusion in dogs) were used to study the antiarrhythmic and antifibrillatory effects. The latters were not inferior to those shown by the well-known antiarrhythmics. The mechanisms of the action of dalargin are discussed in the paper.
ISSN:0869-2092