Effect of high-altitude hypoxia on the effectiveness of chemotherapy in tumors

It was shown in rat experiments that high-altitude hypoxia inhibits the growth of transplantable tumors and enhances the efficacy of antitumor treatment with chemotherapeutic drugs (thiotepa for Heren's carcinoma, and cyclophosphamide for sarcoma 45). Under high-altitude conditions, the cycloph...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 95; no. 2; p. 33
Main Authors Kulish, O P, Galkina, K A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.02.1983
Subjects
Altitude Sickness - physiopathology
Animals
Carcinoma - drug therapy
Cyclophosphamide - administration & dosage
Drug Evaluation, Preclinical
Female
Hypoxia - physiopathology
Kyrgyzstan
Male
Neoplasm Transplantation
Neoplasms, Experimental - drug therapy
Rats
Sarcoma, Experimental - drug therapy
Thiotepa - administration & dosage
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Summary:It was shown in rat experiments that high-altitude hypoxia inhibits the growth of transplantable tumors and enhances the efficacy of antitumor treatment with chemotherapeutic drugs (thiotepa for Heren's carcinoma, and cyclophosphamide for sarcoma 45). Under high-altitude conditions, the cyclophosphamide toxicity as regards blood cells was modified, manifesting in the absence of anemization and less considerable reduction in the platelet and lymphocyte counts. The animals' adaptation to high-altitude hypoxia was followed by a rise in the blood content of sulfhydryl groups and increase in cancerolytic activity of the blood serum.
ISSN:0365-9615