Effect of high-altitude hypoxia on the effectiveness of chemotherapy in tumors
It was shown in rat experiments that high-altitude hypoxia inhibits the growth of transplantable tumors and enhances the efficacy of antitumor treatment with chemotherapeutic drugs (thiotepa for Heren's carcinoma, and cyclophosphamide for sarcoma 45). Under high-altitude conditions, the cycloph...
Saved in:
Published in | Biulleten' eksperimental'noi biologii i meditsiny Vol. 95; no. 2; p. 33 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | Russian |
Published |
Russia (Federation)
01.02.1983
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Summary: | It was shown in rat experiments that high-altitude hypoxia inhibits the growth of transplantable tumors and enhances the efficacy of antitumor treatment with chemotherapeutic drugs (thiotepa for Heren's carcinoma, and cyclophosphamide for sarcoma 45). Under high-altitude conditions, the cyclophosphamide toxicity as regards blood cells was modified, manifesting in the absence of anemization and less considerable reduction in the platelet and lymphocyte counts. The animals' adaptation to high-altitude hypoxia was followed by a rise in the blood content of sulfhydryl groups and increase in cancerolytic activity of the blood serum. |
---|---|
ISSN: | 0365-9615 |