The appearance of a fracture of radioresistant cells in a fibroblast population irradiated at high doses

Two sublines of Djungarian DEF 4/21 hamster cells survived after gamma irradiation with the doses of 10 and 20 Gy were obtained. The survived cell posterity (SCP) of both cell lines are considerably more clonogenic. They show a higher proliferative activity and a shorter period of generation than th...

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Published inRadiat͡s︡ionnai͡a︡ biologii͡a︡, radioėkologii͡a Vol. 37; no. 2; p. 207
Main Authors Tyrsina, E G, Kalendo, G S, Slanina, S V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.1997
Subjects
Animals
Cell Division - radiation effects
Cell Line
Cell Survival - radiation effects
Cells, Cultured
Cricetinae
Dose-Response Relationship, Radiation
Fibroblasts - cytology
Fibroblasts - radiation effects
Gamma Rays
Phodopus
Radiation Tolerance
Time Factors
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Summary:Two sublines of Djungarian DEF 4/21 hamster cells survived after gamma irradiation with the doses of 10 and 20 Gy were obtained. The survived cell posterity (SCP) of both cell lines are considerably more clonogenic. They show a higher proliferative activity and a shorter period of generation than the control cells. The sublines are several times more radioresistant as compared to the original cells. After exposure to high doses of radiation, the cell culture of the SCP exhibits a 17 to 20% high-resistant fraction. Supposedly, the cells of this fraction are responsible for repopulation after exposure to lethal doses of gamma irradiation.
ISSN:0869-8031