The pharmacodynamics of proxodolol when administered once and in a course of doses to patients with stenocardia of effort

The effects of placebo and proxodolol, a new hybrid (beta-, alpha-) adrenoblocking agent, on exercise tolerance, hemodynamics and the conduction system were compared in 28 patients with coronary heart disease, Functional Class II-III exercise-induced angina pectoris at rest and during bicycle ergome...

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Bibliographic Details
Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 57; no. 3; p. 54
Main Authors Petrov, I N, Rumiantsev, A S, Smirnov, M V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1994
Subjects
Adrenergic alpha-Antagonists - administration & dosage
Adrenergic alpha-Antagonists - pharmacology
Adrenergic beta-Antagonists - administration & dosage
Adrenergic beta-Antagonists - pharmacology
Angina Pectoris - drug therapy
Angina Pectoris - physiopathology
Chronic Disease
Dose-Response Relationship, Drug
Drug Evaluation
Exercise Test - drug effects
Female
Hemodynamics - drug effects
Humans
Male
Middle Aged
Oxadiazoles - administration & dosage
Oxadiazoles - pharmacology
Physical Exertion - drug effects
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Summary:The effects of placebo and proxodolol, a new hybrid (beta-, alpha-) adrenoblocking agent, on exercise tolerance, hemodynamics and the conduction system were compared in 28 patients with coronary heart disease, Functional Class II-III exercise-induced angina pectoris at rest and during bicycle ergometric exercise test. Proxodolol was shown to exert a significant dose-dependent antianginal effect without producing any negative effect on atrioventricular and intraventricular conduction.
ISSN:0869-2092