Pure cerebellar syndrome associated with anti-Hu antibodies

Anti-Yo is the most frequent antibody associated with pure paraneoplastic cerebellar degeneration. Cerebellar degeneration may be associated with anti-Hu antibody but other signs of nervous system involvement occur during the course of the disease. We report the case of a 69-year old man presenting...

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Bibliographic Details
Published inRevue neurologique Vol. 151; no. 5; p. 341
Main Authors Pradat, P F, Uchuya, M, Fontaine, B, Lubetzki, C
Format Journal Article
LanguageFrench
Published France 01.05.1995
Subjects
Aged
Aged, 80 and over
Autoantibodies - analysis
Cerebellar Diseases - etiology
Cerebellar Diseases - immunology
Humans
Male
Neurons - immunology
Nucleoproteins - immunology
Paraneoplastic Syndromes
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Summary:Anti-Yo is the most frequent antibody associated with pure paraneoplastic cerebellar degeneration. Cerebellar degeneration may be associated with anti-Hu antibody but other signs of nervous system involvement occur during the course of the disease. We report the case of a 69-year old man presenting with a severe acute cerebellar dysfunction of sudden onset. High titers of anti-Hu antibodies were detected in serum and cerebrospinal fluid by immunohistochemistry and western blot. No other neurological symptom was found after a follow-up of 18 months. Biopsy of a mediastinal lymph node revealed a poorly differentiated carcinoma. We suggest that the course of the anti-Hu syndrome may rarely be similar to the anti-Yo syndrome.
ISSN:0035-3787