Contractile activity and sensitivity of smooth muscle cells of the small intestine to agonists in acute ileus

The impact of acute ileus on the contractility and sensitivity of small intestinal smooth muscle cells to acetylcholine and histamine, as well as possible recovery of smooth muscle cells after removal of 3-hour acute ileus were studied. The contractility of small intestinal smooth muscle cells and t...

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Bibliographic Details
Published inPatologicheskaia fiziologiia i eksperimental'naia terapiia no. 4; p. 48
Main Authors Zaripov, N Z, Krasil'nikov, D M, Chelyshev, Iu A, Akhmedzianov, R Kh, Sibaev, A K
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.10.1994
Subjects
Acetylcholine - pharmacology
Acute Disease
Animals
Cats
Histamine - pharmacology
Intestinal Obstruction - pathology
Intestinal Obstruction - physiopathology
Intestine, Small - drug effects
Intestine, Small - pathology
Intestine, Small - physiopathology
Muscle Contraction - physiology
Muscle, Smooth - cytology
Muscle, Smooth - drug effects
Muscle, Smooth - physiology
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Summary:The impact of acute ileus on the contractility and sensitivity of small intestinal smooth muscle cells to acetylcholine and histamine, as well as possible recovery of smooth muscle cells after removal of 3-hour acute ileus were studied. The contractility of small intestinal smooth muscle cells and their sensitivity to the agonists decreased in proportion to the duration of acute ileus only in the strangulated portion of the bowel. Removal of 3-hour acute ileus resulted in a stepwise recovery of the contractility and sensitivity of small intestinal smooth muscle cells to the agonists in the adducting, strangulated, and abducting portions. It is suggested that in acute ileus, the structure of smooth muscle receptors undergo modification due to tissue homeostatic changes or to the direct action of cell destruction products on receptors.
ISSN:0031-2991