Comparison of haemodynamic effects of pethidine and anileridine in anaesthetised patients

Haemodynamic effects of equianalgesic doses of pethidine (1 mk kg -1) and anileridine (0.25 mg kg -1) were compared in patients with coronary artery disease, after induction of anaesthesia with flunitrazepam - N2O - pancuronium. Contrary to previous findings made in conscious patients, these analges...

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Bibliographic Details
Published inActa anaesthesiologica Scandinavica Vol. 25; no. 5; p. 412
Main Authors Yrjölä, H, Heinonen, J, Tuominen, M, Heikkilä, J
Format Journal Article
LanguageEnglish
Published England 01.10.1981
Subjects
Anesthesia
Blood Pressure - drug effects
Cardiac Output - drug effects
Coronary Disease - physiopathology
Electrocardiography
Female
Heart Rate - drug effects
Hemodynamics - drug effects
Humans
Isonipecotic Acids - pharmacology
Male
Meperidine - pharmacology
Middle Aged
Pulmonary Circulation - drug effects
Time Factors
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Summary:Haemodynamic effects of equianalgesic doses of pethidine (1 mk kg -1) and anileridine (0.25 mg kg -1) were compared in patients with coronary artery disease, after induction of anaesthesia with flunitrazepam - N2O - pancuronium. Contrary to previous findings made in conscious patients, these analgesics produced a moderate circulatory depression. Heart rate, cardiac index and rate-pressure product were decreased by both drugs, and anileridine alone decreased mean arterial pressure. The only statistically significant differences in the haemodynamic changes between the two groups were those in pulmonary capillary wedge pressure and rate pressure product, which were slightly lower after anileridine than after pethidine.
ISSN:0001-5172