Comparative multifactorial analysis of combined administration of injection and peroral forms of an antibiotic with a microbial immunomodulator in experimental anthrax

• Published in: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 36; no. 7; p. 22
• Main Authors: Nikitin, A V, Buravtseva, N P, Fomina, I P, Ivanitskaia, L P, Kogotkova, O I, Bodunkova, L E
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.07.1991
• Subjects: Adjuvants, Immunologic - administration & dosage; Administration, Oral; Animals; Anthrax - drug therapy; Anthrax - immunology; Anthrax - mortality; Disease Models, Animal; Drug Therapy, Combination; Factor Analysis, Statistical; Injections, Intraperitoneal; Male; Mice; Peptidoglycan - administration & dosage; Rifampin - administration & dosage
• ISSN: 0235-2990

Comparative efficacy of the use of injection and oral dosage forms of rifampicin in the subtherapeutic doses in combination with peptidoglycan , an immunomodulator of microbial origin, was studied in respect to experimental anthracic infection with application of multifactorial analysis. It was shown that the antibiotic and immunomodulator had a pronounced synergistic effect. Polynomial statistic models were developed and nomograms or equal level curves defining the survival rate and average life-span (ALS) of the experimental animals within a wide range of the antibiotic and immunomodulator doses and the peptidoglycan dosing time were plotted. The combined use of the injection rifampicin in the subtherapeutic doses and the immunomodulator provided a significant increase in the survival rate and ALS, whereas the use of the oral antibiotic in combination with the immunomodulator increased only the ALS and not the survival rate. Multifactorial analysis proved to be an optimal methodical approach to comparative study of various antibiotic dosage forms used in combination with immunomodulators under experimental conditions.