Possible use of a concentrated vaccine against tick-borne encephalitis for immunizing donors to obtain specific immunoglobulin

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 9; p. 71
• Main Authors: Subbotina, L S, Beliavskaia, N A, Matiukhina, L V, Kopylova, L M, Kul'chitskaia, T I
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.09.1984
• Subjects: Adult; Animals; Antibodies, Viral - analysis; Antibody Specificity; Blood Donors; Encephalitis Viruses, Tick-Borne - immunology; Hemagglutination Inhibition Tests; Humans; Immunization - methods; Immunization, Secondary; Immunoglobulins - isolation & purification; Mice; Middle Aged; Neutralization Tests; Time Factors; Viral Vaccines - administration & dosage; Viral Vaccines - immunology
• ISSN: 0372-9311

The immunization of donors with dried, purified, inactivated and concentrated cell-culture tick-borne encephalitis vaccine, produced at the Institute of Poliomyelitis and Viral Encephalitides in Moscow, has been carried out with the aim of obtaining immune raw material for the production of specific donor immunoglobulin. The high immunogenic potency and low reactogenicity of the vaccine, introduced in 2 injections at an interval of 6 months, have been confirmed. Immunization in 2 injections has proved to be as effective as that achieved by 3 injections. The expediency of the immunization of regularly bled donors has been established: hemagglutinin titers in these donors have been found to be significantly higher than in a group of persons never bled before. The optimum time for taking blood has been determined: 3 weeks for regularly bled donors and 2 weeks for donors bled for the first time. Blood may be taken again 2 months after the first bleeding without booster immunization and 2 weeks after the third injection of the vaccine.