Effect of ethmozin and Ritmilen on microcirculatory hemostasis in patients with heart rhythm disorders

Effects of ethmozine and ritmilen were studied in 75 patients with different disorders of cardiac rhythm predominantly proceeding in the form of extrasystole arrhythmia. The drugs were found to exert a distinct antiaggregant action on platelets and erythrocytes which was particularly pronounced at i...

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Bibliographic Details
Published inFarmakologiia i toksikologiia Vol. 49; no. 5; p. 94
Main Authors Grigor'ev, G I, Petrova, T R
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.1986
Subjects
Adolescent
Adult
Aged
Ajmaline - therapeutic use
Anti-Arrhythmia Agents - therapeutic use
Arrhythmias, Cardiac - blood
Arrhythmias, Cardiac - drug therapy
Cell Aggregation - drug effects
Drug Evaluation
Erythrocyte Aggregation - drug effects
Female
Hemostasis - drug effects
Humans
Leukocytes - drug effects
Male
Microcirculation - drug effects
Middle Aged
Moricizine
Phenothiazines - therapeutic use
Platelet Aggregation - drug effects
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Summary:Effects of ethmozine and ritmilen were studied in 75 patients with different disorders of cardiac rhythm predominantly proceeding in the form of extrasystole arrhythmia. The drugs were found to exert a distinct antiaggregant action on platelets and erythrocytes which was particularly pronounced at intravenous administration and transiently increased the number of leukocytes and their aggregation. A decrease of platelet aggregation was accompanied by an increase of their number and rejuvenascence of thrombocytogram. A marked antiarrhythmic effect was seen in 66% of patients, in the remaining patients cardiac extracontractions became more rare.
ISSN:0014-8318