Surfactant-dependent atelectasis in pulmonary tuberculosis

Using mathematic modelling of the secretion function of type II alveolocytes of the right lung intercellular surfactant production in treated and not treated rabbits with multi cavernous tuberculosis of the lung was evaluated. Correlation between its disorders and frequency of development and dissem...

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Bibliographic Details
Published inArkhiv patologii Vol. 60; no. 5; p. 41
Main Authors Erokhin, V V, Lepekha, L N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.1998
Subjects
Animals
Antitubercular Agents - therapeutic use
Pulmonary Atelectasis - complications
Pulmonary Atelectasis - metabolism
Pulmonary Atelectasis - pathology
Pulmonary Surfactants - metabolism
Rabbits
Tuberculosis, Pulmonary - complications
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - metabolism
Tuberculosis, Pulmonary - pathology
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Summary:Using mathematic modelling of the secretion function of type II alveolocytes of the right lung intercellular surfactant production in treated and not treated rabbits with multi cavernous tuberculosis of the lung was evaluated. Correlation between its disorders and frequency of development and dissemination of atelectatic changes in the organ was revealed. Surfactant-dependent character of alveoli atelectasis in animals receiving a combination of antituberculosis drugs (isoniazide plus rifampycin plus etambutol), a direct effect of these drugs on membranes of the granular endoplasmic reticulum, formation of secretion granules was demonstrated. Daily intravenous administration of amboxol (25 mg/kg) for 14 days had a protective effect on type II alveolocytes, activated surfactant production, prevented alveoli from atelectasis.
ISSN:0004-1955