Diagnosis and treatment of acute progressive tuberculosis types

• Published in: Problemy tuberkuleza no. 5; p. 21
• Main Authors: Khomenko, A G, Mishin, V I
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1996
• Subjects: Acute Disease; Adolescent; Adult; Antitubercular Agents - therapeutic use; Combined Modality Therapy; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - isolation & purification; Physical Therapy Modalities; Retrospective Studies; Tuberculosis, Pulmonary - diagnosis; Tuberculosis, Pulmonary - drug therapy; Tuberculosis, Pulmonary - microbiology
• ISSN: 0032-9533

An examination was made of 77 patients with extensive segmentary and lobular pulmonary tuberculous lesions: caseous pneumonia (n = 26), infiltrative caseous pneumonia (n = 18), fibrocavernous pneumonia complicated by caseous pneumonia (n = 16), and disseminated tuberculosis (n = 17). All patients had destructive changes; in 82.7% of patients the caverns were large and great in size. Bacteria were isolated in 94.8%, mycobacterial drug resistance was noted in 51.8%. Four variants of the course of a disease were identified: 1) that with predominance of the intoxication syndrome (41.6%); 2) that with respiratory failure (24.7%); 3) that with pulmonary hemorrhage (15.6%), 4) that added by secondary microorganisms (18.2%). Chemotherapy included a combination of 4 or 5 drugs along with pathogenetic tools, which stabilized a process in 80% of patients and arrested bacterial isolation in 69.5%. In 20%, the process continued to progress and in 3 of them died.