Interaction between lipid peroxides, the antioxidant system, and levels of cyclic AMP and cyclic GMP in hypoxic and hyperthermic animals

The hypoxic syndrome as the basis of pathothenesis of the mine trauma was studied in experiments on rats. It is established that the latter determines sharp activation of the processes of lipid peroxidation and weakening of the basic components of antioxidant system of the organism with simultaneous...

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Bibliographic Details
Published inUkrainskij biohimičeskij žurnal Vol. 67; no. 6; p. 102
Main Author Savchenkova, L V
Format Journal Article
LanguageRussian
Published Ukraine 01.11.1995
Subjects
Animals
Antioxidants - metabolism
Cyclic AMP - metabolism
Cyclic GMP - metabolism
Fever - metabolism
Hypoxia - metabolism
Lipid Peroxides - metabolism
Rats
Rats, Wistar
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Summary:The hypoxic syndrome as the basis of pathothenesis of the mine trauma was studied in experiments on rats. It is established that the latter determines sharp activation of the processes of lipid peroxidation and weakening of the basic components of antioxidant system of the organism with simultaneous accumulation of leucotrienes B4 in the blood plasma. Besides, the disbalance in the content of secondary messengers--cAMP an cGMP has been established.
ISSN:0201-8470